The Tomazou lab, at the St. Anna Children's Cancer Research Institute in the medical hub of Vienna, aims to establish an epigenome-based precision medicine program for pediatric sarcomas.
The goal of our research group is to uncover the roles of epigenetic deregulation as an oncogenic mechanism, with a focus on fusion-driven pediatric sarcomas. We study how fusion proteins rewire healthy cells for malignancy, with the perspective of exploiting this knowledge for improving pediatric sarcoma therapy. We are applying state-of-the-art technologies that combine wet-lab and computational methods investigating:
Non-genetic mechanisms of tumor formation orchestrated by oncogenic fusion proteins
Contribution of the cellular state of the corresponding cell of origin to cancer development
Epigenetic heterogeneity as source of cellular plasticity providing novel therapeutic paradigms
Non-genetic based biomarkers for patient stratification and real time disease monitoring
For more details on published work, please also see our publications.
Disease modelling of fusion-driven sarcomas & cell-of-origin